I-pulmonary hypertension - iimpawu

I-pulmonary hypertension, okanye i-pulmonary blood pressure, isifo esibonakaliswe nguxinzelelo olwandisiweyo kwinkqubo ye-pulmonary artery. Isizathu esibalulekileyo sesi sifo sivame ukwanda kwenkcaso kumbhede we-vascular of the lungs. Into yesibini echaphazela ukuphuhliswa kwengozi yomshumbuliso yongxowankulu yenyuka kwindleko yokuphuma kwegazi.

Ulwazi olubanzi malunga nesifo

I-pulmonary hypertension ithintela abafazi ngokuphindaphindiweyo njengesondo esinamandla. Umyinge weminyaka yezigulane uneminyaka engama-35. Nangona ukuba le minyaka ingaba kubizwa ngokuba ngumncinane, kumsebenzi weengxaki ze-pulmonary artery zivele zivele.

I-pulmonary hypertension ibhekisela kwiintsapho okanye kwizifo eziphambeneyo. Ukuchaneka, iziganeko eziphambukayo, ezenzeka ngezikhathi kwaye zingekho ngendlela echanekileyo, zivele ziphindwe kabini ngaphezu kweentsapho.

Xa lesi sifo sinobuhlobo bentsapho, kukho umngcipheko ophezulu wokuguqulwa kwegazi kwi-gene receptor ye-bone morphogenetic uhlobo lweprotheni 2. Oku kunokuba nzima ukuba inkqubo yonyango.

Iimpawu zengcinezelo yomsongo ophezulu weplmonta

Izibonakaliso zeprayimari (idiopathic) yomshumbuliso yomshumpulane zininzi:

1. Vasoconstriction. Eli gama lithetha ukuba i-lumen yemithambo yegazi, ingakumbi imirhobho, iyancipha.
2. I-hypertrophy ye-muscle ye-smooth - ukunyusa kweendonga zemithambo yegazi.
3. Ukulungiswa kweendonga zemithambo yegazi. Isibonakaliso sibonakalisa kuyo nayiphi na uhlobo loxinzelelo lwegazi, lubonakaliswe ngoncedo lokuguqulwa kokusebenza kwemisebenzi kunye ne-morphology yemithambo yegazi. Ukulungiswa kwe-Vascular kukuphawu lokuqhubela phambili kwezifo, ngoko oku kuthathwa ngokungathí sina kwaye impendulo ikhawuleza.

Ukongeza, i-vasoconstriction ibonisa utshintsho oluthile emzimbeni. Isibonakaliso sisiphumo somsebenzi okwandisiweyo we-thromboxane, endothelin kunye nokuncipha kwenzo esisebenzayo ye-prostacyclin kunye ne-nitric oxide. Ngaloo ndlela, i-vasoconstrictors iqhutywe kakhulu, kwaye ii-vasodilators zinciphisa umsebenzi.

Iimpawu zokuqala zengcinezelo ye-pulmonary

Isigulane sisesimweni sokufumanisa iimpawu eziqhelekileyo zengxakeko yomshukela, ezibonakaliswa kuqala. Akunakwenzeka ukuba ungaboni ukunyuka kwexinzelelo lwegazi kwisiqingatha. Isigulane sinokukhathala ngokugqithiseleyo, ukuphefumula okufutshane kunye nomthwalo oqhelekileyo kunye nokuphazamiseka esifubeni, ehamba kunye nokuphelelwa amandla . Ezi zimpawu zibizwa ngokuba yimpawu ezingekho ngqo kwi-pulmonary hypertension, kuba ziyakwazi ukubonisa ngezifo ezininzi kunye neengxaki, ngoko zihlala ziphawulwa.

Kwakhona, isigulane ngokukhawuleza silahlekelwa isisindo nokuba sisondlo esipheleleyo, siziva sidiniwe, iimeko zinoloko zibonakala zixinekile, nangona kungekho zizathu. Kwezibonakaliso ezicacileyo, ukukhwehlela okuqhekezayo rhoqo kunye nezwi elikhunjulwayo linokuqatshelwa. Amava engqondo i-oksijini yindlala, kwaye intliziyo iyabetha kaninzi.

Iimpawu zoxinzelelo lwe-pulmonary

Ifomu efanelekileyo yeso sifo yingozi kakhulu, ekubeni iimpawu zayo azichazwanga kakhulu, ngenxa yokuba zifumaneke kuphela kwizigaba zokugqibela zesifo. Into ebalulekileyo yenyuka kwixinzelelo ezimbini okanye ngaphezulu xa kuthelekiswa nesiqhelo.

Ukuqulunqa, singatsho ukuba iimpawu zesifo esiyinkimbinkimbi ziphazamiseke ngokwaneleyo. Ekuqaleni, banokugwetyiswa ngenxa yokukhathala, ukunyuka kokuziphatha okanye ubudala. Kodwa ukuze ugweme iingxaki zempilo ezinzima, kubalulekile ukubonisana nodokotela ngaphandle kokulibaziseka ngeenguqu zokuqala ezingekho emgangathweni kwimpilo.