I-granulomatosis ye-Wegener yisifo esizimela ngokubhekiselele kwizifo ezinzima kwaye zihamba ngokukhawuleza. I- vasculitis yesistimu kunye ne-Wegener's granulomatosis zixhomekeke ngokusondeleyo, kuba i-antibodies (i-antineutrophil cytoplasmic) yenziwa kwi-granulomatosis, eyinto ephawulekayo ye-vasculitis e-ANCA.
Iimbangela ze-granulomatosis ye-Wegener
I-granulomatosis ye-Wegener ibhekisela kwi-autommune, ngoko kuya kuba ne-genetic factor. Enyanisweni, i-granulomatosis iyimpendulo engagunyazisiyo yomzimba. Ngoko ke, abamakishi besi sifo banama-antigen-HLA 〖B〗 _7, B_8, 〖DR〗 _2, 〖DQ〗 _w7.
Inendima yezilwanyana eziphilayo zidlalwa ngama-antineutrophil anti-cytoplasmic antibodies esebenza ngeproteinase-3.
I-granulomatosis ye-Wegener - iimpawu
Iimpawu ze-granulomatosis zidla ngokugqithiseleyo kwiminyaka engama-40, ngelixa i-gender factor does not matter.
I-Granulomatosis - ukuvuvukala kweendonga zeenqanawa ezincinci neziphakathi: ii-venules, i-capillaries, iirrioles kunye ne-arterioles. Kwinkqubo yokutshatyalaliswa, inqanaba eliphezulu lokuphefumula, izintso, amehlo, imiphunga kunye nezinye izitho zibandakanyeka.
Izimpawu zilandelayo:
- jikelele - ukulahlekelwa kwesisindo, ubuthathaka, i-myalgia, i-arthralgia, umkhuhlane, kwiimeko ezinqabileyo, i-arthritis;
- inkqubo ye-nervous-asymmetric polyneuropathy;
- amehlo - ischemia yentsholongwane ye-optic, imfama, i-episcleritis enegranuloma ye-orbital kunye ne-exophthalmos;
- i-skin-rashes nge-necrotic elements;
- izintso - glomerulonephritis , ezinokuthatha ikhosi yokuzila;
- iimpompo zikhula kwi-75% yezigulane ngendlela yokungena ngaphakathi, ezenza izibonda ngexesha lokubola; nale nto ingabonwa yi-pleurisy, ukukhwehlela.
- Iiphetshana zokuphefumula - zithinteka kwi-90% yezigulane ngendlela ye-rhinitis ene-purity-haemorrhagic secretion kunye nesilonda; Ukugqithiswa kwe-nasum ye-nasum kuholele ekuhambeni kwe-deformation; Kwakhona, lesi sifo sichaphazela i-larynx, iindlebe, i-trachea, i-sinanas sinuses, apho kuboniswa khona inqubo engathandekiyo.
I-granulomatosis ye-Wegener ineendlela ezimbini:
- kwindawo echaphazelekayo-ichaphazela ikakhulu umzila wokuphefumula;
- jikelele - kunye namalungu amaninzi achaphazelekayo, kwaye oku kuhambelana nomkhuhlane, iintlungu zomzimba, ukukhwehlela kunye nokungaphumeleli kwentliziyo.
Ukuxilongwa kwe-granulomatosis ka-Wegener
Olu xilongwe lwenziwa yirheumatologist esekelwe kwiinkcukacha ezininzi:
- iimvavanyo zegazi - i-biochemical and general, ezingenakuqinisekisa i-granulomatosis, kodwa uncedo lokulawula ezinye izifo;
- Uhlalutyo lomchamo - luyakwazi ukuqinisekisa okanye ukungabandakanyi umonakalo wento (uhlobo lwesifo luzimisele);
- I-X-ray yesinus paranasal kunye ne-thorax (i-computed tomography inikeza ulwazi oluchanekileyo kunokuba lufunyenwe ngu-X-ray);
- i-biopsy - indlela kuphela eqinisekisa ngokuqinisekileyo okanye ephika ubukho be-granulomatosis; oogqirha bathabatha izicubu empumleni okanye emqaleni, kwaye kwezinye iimeko, iintso kunye nemiphunga.
Unyango lwe-wegener's granulomatosis
Ukunyangwa kwesi sifo kwenziwa, ngokukodwa, ngokuthatha inxaxheba kwe-corticosteroids kunye ne-cytostatics, eyanciphisa umsebenzi
Ngomonakalo omkhulu weentliziyo, kwezinye iimeko, isigulane sidinga ukufakelwa komzimba.
I-granulomatosis ye-Wegener - ukuhlaziya
Ukuba unyango aluzange luqalwe ngendlela efanelekileyo, ngoko ukuhlaselwa okungahambi kakuhle kuya kuzaliseka kwiinyanga ezili-6 ukuya ku-12, kwaye ubude bomyinge obuncinane abudluli kwiinyanga ezi-5.
Kwimeko yonyango, ukuxolelwa kuqhubeka malunga ne-4 iminyaka, kwezinye iimeko iminyaka eyi-10. Ukunyanga okupheleleyo kwinqanaba langoku lokuphuhlisa amayeza akunakwenzeka.