I-Triiodothyroxine okanye i-T3 yi-hormone eveliswa yi-thyroid gland ngesiseko se-tetraiodothyroxine (T4), ngenxa yokutshatyalaliswa kwayo. Iveliswa kumthamo omncinci, kuphela i-10%, nangona kunjalo yinto ephambili yezinto eziphilayo ezichaphazelekayo zesitho se-endocrine.
Ngokuqhelekileyo ukuvavanya imisebenzi ye-thyroid gland kuyimfuneko ukucacisa i-T3 yamahhala - luhlobo luni lwe-hormone kwaye yintoni ejoliswe kuyo, yazi ezimbalwa. Nangona kunjalo, le fomu ye-triiodothyroxine ithathwa njengeyona nto ibalulekileyo ye-metabolism yamandla emzimbeni.
Yintoni i-hormone yeTroid ephendula ngayo?
I-precursor yezinto ezinokuqwalaselwa yi-tetraiodothyroxine, equle i-molecule i-iodine. I-T4 yi-hormone esebenzayo, iveliswa yi-thyroid gland ngobuninzi (malunga ne-90%).
Emva kokuhlukana kwe-molecule enye ye-iodine ukusuka ku-tetraiodothyroxine, i-T3 yenziwa. Le hormone iphindwe ngokuphindaphindiweyo kwe-T4, ixanduva lweenkqubo zokunikezelwa kwamandla, ukuphuculwa komsebenzi weentlanzi, kubandakanya umsebenzi wengqondo. Enyanisweni, i-triiodothyroxine yiyona nto ikhuthaza ngayo yonke inkqubo ebalulekileyo emzimbeni.
Xa i-T3 ingena kwigazi, ibopha kwiiprotheni. Benza umsebenzi wokuthutha, ukuhambisa i-hormone kulawo malungu kunye nezicubu, apho kukho isidingo esiphuthumayo. I-triiodothyroxine eboshiweyo ekuhlalutyweni kuthiwa i-generic.
Inani elincinci le-hormone lihlala egazini leeprotheni ezingenakunqandwa, yile T3 ikhululekile. Ingcamango yayo ithathwa njengeyona nto eyiyo ekufundeni umsebenzi we-thyroid, ekubeni i-triiodothyroxine engabonakali iyasebenza kwaye ivelise iziphumo ezikhankanywe ngasentla.
Free hormone T3
Ama-laboratories ahlukeneyo amisela imida yabo eqhelekileyo yezinto ezinombuzo. Zixhomekeke kwindlela yokubala ingcamango yayo, iiyunithi zokulinganisa nokuvalelwa kwezixhobo ezisetyenziswayo.
Ukuhlaziywa kwe-immunochemiluminescent echanekileyo, ixabiso elichazwe kwi-2.62 ukuya ku-5.69 i-nmol / l. Ekubeni zixhobo zokusebenza ezincinci, umda osemgangathweni wesiqhelo udlalwa kakhulu, 5.77 nmol / l.
Ngenxa yintoni i-hormone ye-T3 ekhululekile?
Ukugqithiswa kwiimpawu eziqhelekileyo eziqhelekileyo kubonisa ukuba izifo ezahlukeneyo okanye iziganeko zexeshana zomzimba ezibangelwa unyango oluthile.
Izizathu eziphambili zokukhulisa i-hormone T3 mahala:
- ubuninzi besisindo somzimba esinconywayo;
- ikhosi ye-hemodialysis esanda kuzaliswa;
- i-thyroid ukungasebenzi (okwethutyana) emva kokubeleka;
- i-myeloma inxulumene nexinaniso ephezulu ye-immunoglobulin G;
- ukuxhatshazwa okanye i-thyroiditis;
- isifo esingasasigxina sesibindi;
- i-nephrotic syndrome ekuphuhliseni i-glomerulonephritis;
- Usulelo lweHIV;
- choriocarcinoma;
- hyperestrogenia;
- porphyria ;
- ukuhambisa i-goiter enobuhlungu;
- ukwamkela i-hormone ye-thyroid eyenziweyo, iintlobo ezahlukeneyo zokukhulelwa komlomo, i-methadone, i-cordarone.
Kuyimfuneko ngokukhawuleza ukujongana ne-endocrinologist ukuba i-hormone T3 ekhululwa ikhululekile-unyango oluqalwe ngexesha, kuya kunceda ukuphepha iingxaki zezifo ezichazwe, ukukhusela ukukhula kwee-aplasmic ne-metastasis ezimbi.
Kutheni iHymmone T3 ikhululekile?
Ukuncipha kwinani le-thirotoxin elingabonakaliyo aliyingozi njengoko ukwanda kwalo. Izizathu eziphambili zeziphumo ezinjalo
- Ukungakwazi ukusebenza komsebenzi;
- ukugula ngengqondo;
- ukutya okuphantsi kwiprotheni;
- hypothyroidism ;
- ukubuyisela kwisifo esibi;
- unyango kunye nama-statins, anabolic, iziyobisi ezichasayo, izidakamizwa ze-antithyroid, i-steroids;
- Ukwamkelwa kwangoko kwezaziso ze-radiocontrast.