Izidakamizwa ezichasayo ezingabhubhisiyo (i-NSAID) liqela lamayeza asebenzayo anesifo esichaphazelekayo sokulwa ne- antipyretic, anti-inflammatory and analgesic.
Ngaloo ndlela, ezi nkunkuma zinceda ukunciphisa intlungu, umkhuhlane kunye nokuvuvukala. Isenzo sabo sisekelwe ekukhuselweni kwee-enzyme ezithile, apho ukuhlanganiswa kwezinto ezithintela inkqubo yokuvuvukala kwenzeka emzimbeni. Ngokuchasene ne-glucocorticoids (i-agents e-hormonal), umphumo wokuba ufana neyayiyo, inkunkuma ye-non-steroid imithi ayinayo inqwaba yeepropati ezingathandekiyo.
Ukongezelela, ezinye ii-NSAID zinefuthe lokusasaza (ukuhlengahlengiswa, ukuphuculwa kwe-fluidity yegazi), kwakunye nomphumo wokuzikhusela komzimba (ukukhutshwa komzimba wokuzikhusela).
Imiqondiso yokusetyenziswa kwe-NSAID
Ngokuqhelekileyo, izidakamizwa ezingekho-steroidal ezichasayo ziyasetyenziswa kwizifo ezinzima kunye nezifo ezingapheliyo, ezihamba kunye nokuvuvukala nentlungu. Makhe sibhale uluhlu lwamathala, apho kulungiselelwa khona amalungiselelo alandelayo anikezelweyo:
- osteoarthritis;
- i-rheumatoid arthritis;
- gout;
- intloko, i- migraine ;
- umkhuhlane;
- izifo zengqondo;
- dysmenorrhea;
- colic renal;
- amathambo asemathambo;
- syndrome yesifo;
- ukuxhamla.
Uluhlu lwezilwanyana ezingenayo i-steroidal anti-inflammatory
Uludwe lwezidakamizwa zamanqatha ezingabhubhisiyo namhlanje zibubanzi ngokubanzi. Zihlelwe ngokwemimiselo yeciksi kunye nemvelo yalo msebenzi. Iifom ezahlukeneyo ze-non-stteroidal anti-inflammatory zihlukaniswe: iipilisi, iipsulules, i-ointments, i-gels, i-suppositories, izisombululo ezingenayo, njl.
Cinga ngeentlobo eziphambili ze-NSAID:
- Salicylates:
- Aspirin;
- Diflunisal;
- lysine monoacetyl salicylate.
- Indomethacin;
- Sulindak;
- Le eelander.
- Diclofenac ;
- Aceclofenac.
- Ibuprofen;
- Ketoprofen;
- Tiaprofenic acid;
- Naproxen;
- Flurbiprofen;
- Fenbufen;
- Fenoprofen;
- Nabumethon.
- Lornoxicam;
- Tenoxicam;
- Piroxicam;
- Meloksikam.
- Rofecoxib;
- Nimeslide;
- Celecoxib.
Ukususela kumalungiselelo anikeziweyo malunga nesenzo sokuhlaselwa, izidakamizwa ezifana neKetorolac, Ketoprofen, Diclofenac, i-Indomethacin ziphumelela kakhulu. Iipropati eziphambili zokulwa nezidumbu ziyi-Indomethacin, i-Flurbiprofen, i-Diclofenac ne-Piroxicam.
Kubalulekile ukuba uqaphele ukuba izidakamizwa ezingekho-steroidal ezichasayo zithengiswa phantsi kwamagama amashishini athile. Ngoko ke, xa kuthengwa iyeza kwikhemistri, okokuqala, umntu makayiqwalasele igama lehlabathi.
Izidakamizwa ezichasene nezidakamizwa zesizukulwana esitsha
Izidakamizwa ezichasayo ezingabhubhisiyo zesizukulwana esitsha zisebenza ngokukhethekileyo kwaye zibonisa umsebenzi ophezulu xa kuthelekiswa nabaphambili. Kule meko, akukho miphumo echaphazelekayo evela kwiphepha lesisu.
Abameli bamachiza amatsha e-NSAID iqela li-oxycam.
I-NSAID nazo zichasene nazo:
- izilonda ezinobomi kunye nezilonda zesigca esisisu;
- ukuphulwa kwebindi kunye neentso;
- cytopenia;
- khulelwa;
- ukunganyamezeli.