I-hemoglobin ye-Glycated enye yezinto ezinokwenziwa kwezinto eziphilayo ezibonakalisa izinga eliphakathi kweswekile kwigazi ixesha elide. Uhlalutyo lwe-hemoglobin ene-glycated inendima ebalulekileyo ekuxilongweni kwesifo sikashukela, kunye nokubeka iliso kwimeko yezigulane ezixilongwa.
Uhlalutyo lubonakalisa njani i-hemoglobin ye-glycated?
I-hemoglobin ene-glycated ikhona kwigazi lomntu ngamnye, kwaye ixabiso layo lichongiweyo njengepesenti yehemoglobin egazini.
I-hemoglobin ye-Glycated yenziwa ngenxa yokuxuba kwe-glucose kunye ne-hemoglobin, apho i-enzyme ayithatha inxaxheba. Ngenxa yoko, kukho umxube oqhubekayo ongaqaliyo kwaye ukhona kwiiseli ezibomvu zegazi (i-erythrocytes) lonke ixesha lobomi babo. Ekubeni i-hemoglobin ene-glucose ayibopheli ngokukhawuleza, kwaye ixesha lokuphila lamaseli obomvu lingabakho kwiintsuku eziyi-120, eli lathisi lithetha ukuba ayikho inqanaba langoku leeshukela egazini, kodwa lilinganiselwa kwiinyanga ezi-3.
Iphakanyisiwe kwaye inciphise i-hemoglobin eglycated
Ngeenjongo zokuxilonga, olu hlalutyo lusetyenziselwa isifo sikashukela semimandla yazo zonke iintlobo kunye nezimo zesifo sesifo sesifo sikasifo sikasifo sikasifo sikasifo sikasifo sikasifo sikasifo. Ukuphakama kwinqanaba leswekile, i-hemoglobin ngakumbi iboshwe, kwaye ngoko-hemoglobin i-glycated iphakanyiswe phezulu kwizigulane ezinesifo sikashukela.
Isiqhelo sithathwa njenge-4 ukuya kwi-6%, kunye ne-hemoglobin ene-glycated ukusuka kwi-6.5 kuya ku-7.5% yimeko yesifo sesifo sikasifo sesifo sikashukela, ixabiso eliphezulu libonisa ukuba khona kwesifo sikashukela esingahlawulwanga. Ukongezelela, ukusilela kwesebe kungabangela.
Nangona kunjalo, kukho iimeko ezininzi zezifo, ngenxa yokuba i-hemoglobin ene-glycated ingaba yanda okanye iyancipha, kwaye umfanekiso weklinikhi uphazamiseka.
Isalathisi singanyuswa nge:
- Ukunqongophala kwesinyithi (kule meko, ukungasebenzi kwe-anemia ye-iron iyaqhubeka, inani elipheleleyo le-hemoglobin egazini liyancipha, ngoko ke isalathisi esinxulumene naso siphezulu);
- utyhefu kunye nosawoti okhokelayo okanye utywala;
- Ukungaphumeleli kwezintso ngenxa yokuqokelela kwigazi lemveliso yokubola, engagqithwanga emzimbeni;
- ipeni elide.
Ixabiso le-hemoglobin elinciphileyo linciphisa xa lithe:
- kuphuma;
- i-hypoglycemia ende;
- i-hemolytic anemia (apho ubude bomzimba obomvu bamaseli ehla);
- emva kokumpontshelwa igazi.
Ukuhlolwa kwegazi nge-hemoglobin eglycated
Ngokungafani neemvavanyo ezininzi, ukunikela ngegazi ukutyumbela i-hemoglobin akunakwenziwa kwisisu esingenalutho. Ekubeni olu hlolo lubonisa izinga lokushukela eliphakathi kwenyanga e-ezintathu, izikhombisi zamanje zingenakuchaphazela.
Kwakhona, inqanaba le-hemoglobin e-glycated ayithinteki okanye ithonyelwe ukutywala kakhulu kuninzi lweziyobisi, izibanda kunye nezifo zokuphefumula, isimo sengqondo somguli. Izikhombisi ziyakuthi zichaphazeleke ngelahleko yegazi (kunikezelwa ukukhubazeka kwimijikelezo yokuya esikhathini kunye nokuphuma kwamanzi amaninzi) kunye nezinye
Ukongezelela, ukuphazamisa izikhombisi (zinciphisa kancane) zingathabatha iintsuku ezimbalwa ngaphambi kokuvavanywa kwamalungiselelo ensimbi, ukusetyenziswa kwenani elikhulu lezinto ezinobumba kunye newayini elibomvu. Ukuba izidakamizwa zandisa inani lilonke le-hemoglobin zithathwa rhoqo, ngoko aziphambukisi umfanekiso weklinikhi.
Kufuneka ikhunjulwe ukuba uphando malunga ne-hemoglobin ye-glycated kwiikliniki ezahlukeneyo (ukusebenzisa iindlela ezahlukeneyo) kunokubonisa iziphumo ezahlukeneyo. Ngoko ke, ukuba uvavanyo luqhutywa rhoqo, ukubeka esweni imeko jikelele, kungcono ukusebenzisa ii-laboratory enye.