I-tumor necrosis ibizwa ngokuba yi-procellular polyproctional protein, eyenziwa ngama-cell immunocompetent (macrophages, eosinophils). Ngokwenza kwezinye iiseli zomzimba, le protein ibangela iziphumo ezilandelayo:
- ukukhawuleza kwe-lipid metabolism;
- utshintshe ekuphepheni kweendonga zemithambo yegazi;
- ukwanda kwemveliso ye-interleukines (1, 6, 8);
- ukukhuselwa kwiipasellular parasites;
- umgaqo wokuveliswa kwe-antibody;
- nentsingiselo.
Ukuhlolwa kwegazi nge-tumor necrosis
Ekubeni i-tumor necrosis inxaxheba ithatha inxaxheba kwimilinganiselo yonke yokuzikhusela komzimba, ukugxininiswa kwegazi kwinqanaba lezinto ezivuthayo. Ukuba ukuhlolwa kwegazi kubonisa ukuba i-tumor necrosis yinto ephakamileyo, ngoko oku kungabonisa loo mathambo:
- Izifo ezithathelwanayo (i-hepatitis C, usulelo lwe-herpes, endocarditis, njl.);
- sepsis ;
- imeko yokuphazamiseka;
- isicic heart disease;
- psoriasis;
- izifo ezikhoyo;
- ukulahlwa kwamatyala okutshintshwa;
- i-atherosclerosis yeemithambo zeentliziyo kunye nengqondo;
- i-bronchopulmonary pathologies engapheliyo;
- izifo ;
- izifo,
I-tumor necrosis into ebalulekileyo kwi-oncology
Ukuqaphela inani le-tumor necrosis kubalulekile ekuhloleni ikhosi yomhlaza. Ngokumalunga neeseli ze-tumor, le protein ibonisa umsebenzi, obonakaliswa kwi-necrosis eneemvakalelo ezinamayeza angenayo i-nonoplastic ngaphandle kokutshabalalisa amaseli aphilileyo. Ngokusekelwe kwi-tumor necrosis into ekhethiweyo ngendlela ekhethekileyo esuka kwigazi lomnikeli, izidakamizwa eziphathekayo eziphathekayo ziveliswa, ngelixa zinefuthe elibi kakhulu emzimbeni. Ngokomzekelo, ngoncedo lweziyobisi Ukunikwa ngonyango lwe-cancer yombele kwenziwa.