I-Estradiol yi-hormone yesini esetyhini esuka kwi-estrogen iqela, elalikhutshwa kakhulu ngamaqanda (kwinani elincinci lihlanganiswa ngama-adrenal glands). Iqondo le-hormone le-estradiol kubasetyhini liyahluka ngokuxhomekeka kwisigaba somjikelezo wesini. Ukuveliswa kwe-estradiol kukhuthazwa ngama-hormone okukhupha i-pituitary gland. Kwinqaku lethu, sifunda oko kuthintela ihomoni ye-female i-estradiol kwaye yintoni ingozi xa kwenzeka ukuphambuka kweso siqhelo.
Ihommone estradiol - yintoni inoxanduva?
Njengoko kuthethwe ngaye, ukuveliswa kwe-Luteinizing (LH) kunye ne-follicle stimulating (FSH) i-hormone kwi-pituitary gland ivuselela ukuveliswa kwe-estradiol ngama-ovari. Umsebenzi oyintloko we-estradiol yinto enokubakho kokukhula kobugqwetha kunye nokukhula kocwangciso olusebenzayo lwe-endometrium. Ngethuba le-ovulation, ubukhulu bomgca wangaphakathi we-endometrium kufuneka kube ubuncinane be-10 mm. Ukungabikho kwe-estradiol kukuvimbela ukukhula kunye nokukhula komsitho obuninzi-ke ngoko, ukuvuthwa kungenakwenzeka. Ukukhula kwe-endometrium esebenzayo kuya kuvinjelwa. Kwiimeko ezinjalo, iqanda elinomsolo oluphumeleleyo alinakufakwa kwisalathisi sesisu kwaye kuya kubakho ukuphuphuma kwesisu ekuqaleni.
Ukuthetha ngemisebenzi ye-estradiol, asikwazi ukuthetha ukuba nguye owenza umfazi omhle. Ngaphantsi kwempembelelo yehomonikazi ye-hormone estradiol, isalathisi sesibhakabhaka sakhiwa (isifuba esikhulu, isikhumba esincinci sinokutshintshela kwinqaba), ulusu luba luhle kwaye lube lukhuni, kwaye luvimbela ukukhula koboya kwiindawo eziqhelekileyo zamadoda (ubuso, isifuba, imilenze, isisu).
Uhlalutyo lwe-estradiol kubasetyhini
Uhlalutyo lwe-estradiol luqhutyelwa ngumzekelo wesampula wegazi kwisisu esingenalutho. Iqondo le-hormone ye-estradiol ngokuqhelekileyo liyahluka ngokuxhomekeka kwisigaba somjikelezo. Ngoko, iqalisa ukuphuhliswa ukusuka kwiintsuku zokuqala zomjikelezo wokuya esikhathini (kwisigaba sesigxina, inqanaba le-estradiol lisukela kuma-57-227 pg / ml). Ngaphakathi komjikelo, isiqalo se-estradiol sisona sikhulu (ngaphambi kokuba u-ovulation izinga le-estradiol likwinqanaba le-27-476 pg / ml), apho amahora angama-24 ukuya ku-37 aya kuphulukana nokuqhekeka kobugqwetha kunye nokuqala kwe-ovulation. Emva kokugqithisa, izinga le-estradiol liyancitshiswa. Ngoko kwisigaba sokuloba i-77-227 pg / ml. Amanqanaba aphezulu e-estradiol kubasetyhini kwisigaba sesithathu somjikelezo wesini ubonisa ukuqala kokukhulelwa.
Ngexesha lokukhulelwa, izinga le-estradiol kubasetyhini landa ngokunyuka, lifikelela kwinani eliphezulu ngaphambi kokubeleka. Emva kokungena kwiintsuku ezine-4-5, izinga le-estradiol egazini lihla kakhulu.
Umgangatho we-estradiol ngaphantsi kwesiqhelo kubasetyhini unokuba kwezi zizathu zilandelayo:
- ukutshaya;
- yokutya imifuno;
- ukulahleka kwesisindo;
- ukuveliswa kwemiphumo ye-hormone yesini;
- ukutshatyalaliswa kweengcambu;
- umsebenzi owenziwe ngokweqile.
- kwandisa ama prolactin.
Ngethuba lexesha lokumisa kwimiba, inqanaba le-estradiol liyancitshiswa kwaye libubanzi be-19.7-82 pg / ml. Ukwandisa izinga le hormone ngexesha lokumisa umva kungathetha ngezidumbu ezibi ze-ovari.
Umgangatho we-estradiol kumadoda
Ngomzimba wesilisa, i-estradiol iveliswa kwiisisiti zamathambo kunye neengqungquthela ze-adrenal ngenani elincinci. Ngokuqhelekileyo izinga leli
Ngoko, sihlolisise amanqanaba aqhelekileyo e-estradiol kumfazi, kwakunye nezizathu zokunyuka kwawo kunye nokuhla. Ngenxa yokungabikho kwe-estradiol kumzimba wesibhakabhaka obangelwa yindoda yokuqala, ukugonywa kunye ne-radiation castration, i-hypo- and amenorrhea, ukufumana isalathisi sayo esenziwe ngokuchanekileyo kuboniswe. Ngaloo ndlela, ukulungiswa kwe-17-beta estradiol (estradiol e2) kufana ne-estradiol yemvelo kwaye ifumaneka njengamafutha atshintshisayo, isisombululo samanzi, i-spray and spray. Isiza lithathwa kuphela emva kokubonisana nodokotela.