Isifo se-Paget singe-pathologies engokwemvelo. Ngokukodwa esi sifo sichaphazela isifuba . Cinga ukuphulwa ngokubanzi, ukugqamisa izizathu, izigaba, iimpawu kunye nezindlela zokuzimisela, iindlela zokonyango.
Isifo sikaPaget - yintoni na?
Isifo sikaPaget sesibongo sagqitywa ngamagama emva kogqirha oye wahlola le ntsholongwane. Ngokukhawuleza waqala ulwalamano phakathi kweenguqu ezithe zenzeka kwesi sifo, ngomhlaza wesibele. Kwiimeko ezininzi, ukuphulwa kolu hlobo kubhalwa ngexesha lokutshintsha kwe-hormonal - ukuphuma kwesikhashana , ukuphuma kwesikhashana.
Umhlaza wePaget, iimpawu zazo ezichazwe ngezantsi, zikhula kwi-ingono yebele, ngenxa yenkqubo ye-cancer kwisifuba. Utshintsho luya kwesikhumba se-ingono. Kule meko, i-tumor, i-tumor ebulalayo ingenakucatshulwa oogqirha, isigulane ngokwalo. Ngamanye amaxesha, ukuphulwa kungabhalwa kwamanye amalungu - umhlaza wesiqhelo. Kule meko, indawo yokuhluma, isisu, isisu sichaphazelekayo.
I-Paget's Cancer - Species
Umhlaza kaPaget unesi sifo esininzi esinemiboniso eyahlukeneyo yekliniki. Ngenxa yoko, kunzima ukuyixilonga kwiinqanaba zokuqala. Ngokuxhomekeke kwindlela ukukhubazeka kwezifo ezibonakalisa ngayo, iziganeko eziqhelekileyo zekhosi yazo, ezi zilandelayo zifo zilandelayo:
- Ukugqithiswa okubhaliweyo. Ngale fomu kwiphondo elisondezayo kufuphi, kutyalwa iinqwelo ezincinane. Emva kwexesha, baba zilonda.
- I-Examoid engapheliyo. Phezulu kwimbumba, ifom ye-crusts. Xa zisuswe, ummandla omncinci wokwenziwa kwe-intertrigo uyenzeka.
- Ifomu ye-Psoriatic. Ubonakaliswe bubungqina obuphezulu emgodini we-hue encinci, i-pink, i-papules. Ngaphandle, zigqutywe nge-scaly, ezithatha ixesha elide.
- Ifom yobomi. Kuphezulu kwentsiba, kunye nale hlobo lentsholongwane, izilonda zenziwa, kunye nokudakumba kwiziko. Kubukeka ngathi kufana neentaba ze-volcanic.
- Ukuxhamla. Ebonakalayo ngokubonakala komnxeba, uhlobo lwesisu. Ingingqi ingakumbi kwindawo esondayo.
Ngokutsho kweekliniki, kwi-50% yeziganeko, isifo sikaPaget sihamba kunye neenguqu kwi-complex-alveolar complex. Kwi-40% yezigulane ezinokubamba i-palpation kunye noviwo, i-node ye-tumor ephazamisayo kwindawo ebonisiweyo ifumaneka. Esi sifo sifunyenwe kaninzi ngeemviwo zokukhusela, ngenxa yokungabikho komfanekiso weklinikhi.
Umhlaza wePaget - izigaba
Isifo (umhlaza) wePaget sikhula kancane kancane, sinesiqalo esinesidima. Ngenxa yoko, abaninzi abafazi abaqapheli ukutshintsha ixesha elide. Umhlaza wePaget, isigaba sokuqala sesi sifo, ufunyaniswa kakhulu kunqabile, kuba le ntokazi ayinanto. Kwimeko yokukhubazeka, kuyaqhelekileyo ukuhlukanisa izigaba ezine:
- Isigaba 0 - i-tumor igcinwe kwiisisipha ze-epidermal, ngelixa i-formid, inzulu, iimeko ezimbi zikhoyo. Iiprotoksi zihlala zingatshintshi;
- Isigaba 1 - ehamba kunye nesifundo somhlaza wesifuba, isilonda seengcambu zengqungquthela, ezi tshintsho zilapha kufuphi nomlenze;
- Isigaba sesi-2 - sidibene nomdlavuza webele we-intra-cellular;
- Isigaba sesi-3 - sichazwe ngumhlaza wesibeleko, unomdlavuza obunzima, umonakalo omkhulu wesikhumba.
Isifo sePaget sesibetho
Umhlaza wePaget wesifuba, iimpawu zazo ezingekho kwizigaba zokuqala, zihlala zikumangaliswa yintokazi. Uninzi lwezigulane aluqapheli utshintsho kwiimeko zabo zempilo. Izigxeko ziyakwenzeka kuphela ngesisa kwisifuba kunye nokufunyanwa kweempawu. Ukongeza, kwindawo yengono kukho ukucaphuka, ubomvu, ukukhangela kwesikhumba. Xa umhlaza wePaget ukhula, ingono ingabonakali - iyawela ngaphakathi.
Ngenxa yokugula njengesifo sikaPaget, iimpawu ziyakonakala ngokukhawuleza, kodwa oku akunjalo. Ukunyamalala okwethutyana kweempawu kuphawulwa malunga nemvelaphi ye-corticosteroid-ointments - abafazi bathatha iimpawu zokudabuka. Ngokuqhubela phambili kwe-pathology, ukungena kwe-stagnant, i-hyperemia yesithili se-alveolar iyaqhubeka. Njengomphumo weenguqulelo ezinjalo, izidumbu kunye nezilonda zenziwa phezu kwesikhumba, ngoko i-crusts. Izigulana zirekhoda ukubonakala:
- ukubetha;
- kutsha;
- i-tingle.
- ubukhulu bobukhulu kwimimandla engumlomo.
Isifo sePaget - ukuxilongwa
Ukuxilongwa "komhlaza wesifuba wePaget" kubonakaliswe kwisiseko seziphumo zee-laboratory izifundo, umfanekiso weklinikhi. Ukuba ukrokreza isifo, izigulane zinikezelwa:
- uvavanyo lwe-cytological (ukutshitshisa ukusuka kwiphepha elichaphazelekayo)
- I-Histology - i-microcopy yesayithi yeethambo ezilinakele
- mammography.
Umhlaza wePaget - unyango
Isifo sePaget sesifuba sisoloko sithotyelwa unyango. Olu luhlobo oluphambili lweyeza. Ngaphandle kokungabikho kwezibonakaliso ezinokubakho, oogqirha benza uncedo olubanzi lokungenelela. Ngelo xesha, kuyimfuneko ukuphicotha i-lymph nodes. Xa isi sifo sidibaniswa nomdlavuza we-protocol ukungena ngaphakathi, i-mastectomy (ukususwa kwe-gland) yenziwa.
Ezinye iindlela zokunyanga esi sifo zinemiphumo engaqinisekanga. Ngenxa yoko, zisetyenziswe njengongeziweyo. Phakathi kwazo:
- yonyango ;
- chemotherapy;
- unyango lwe-antiestrogen.
Umhlaza webele wePaget - ukuxela
Ngesifo esinjengomhlaza wesibeletho sePaget, ubungqina bowesifazane bungafanelekanga. Ubunokwenzeka bokuphindaphinda kwe-pathology, ukuqala kwakhona kwesi sifo kuqhubeka emva kokusebenza. Ukuxhaswa kukuxhomekeka kwintlungu yokukhula kwesisu. Umyinge wokuhlala kwithuba lokuphila kwesifo sikaPaget yiminyaka emithathu. Ukuba kukho iinxalenye ezingenayo ukungena ngaphakathi, i-metastases, ke eli xesha liyancitshiswa lonyaka.