Iyonke i-immunoglobulin E (Ig E) yinto ebalulekileyo yeempendulo ze-anthelmintic kunye nesalathisi seempendulo zokuphazamiseka zoluhlobo olusondeleyo. Uvavanyo lwe-Ig E lisetyenziselwa ukuxilonga i-allergies ezahlukeneyo kunye ne-helminthiases (i-atopic dermatitis, i-urticaria, i-asthma ye-bronchial).
Yintoni ekhoyo ye-immunoglobulin E?
Iyonke i-immunoglobulin E ikhusela iimbumba zangaphandle zomzimba zangaphandle ngokusebenza kwendawo yeeseli zombane kunye neengxaki ze-plasma ngokunciphisa ukuphendula okuvuthayo. Ngokungafani nezinye iindidi ze-immunoglobulins (D, M, A, G), kubangelwa ukukhuthaza izicubu kwiimpawu, eziqinisekisa ukuphuhliswa okukhawulezileyo kwempendulo. Ig E iveliswa apha. Oku kwenzeka ngokukodwa kwicandelo elincinci le-tissue, ehlala idibana nommandla wangaphandle. Kungaba:
- isikhumba;
- toni;
- adenoids;
- phefumla;
- iphepheni lesisu.
Xa i-allergen ingena emzimbeni womntu, inxibelelana kunye ne-immunoglobulin e-Ene. Le nkqubo ihambelana nokukhululwa kweeseli ze-histamine kunye nezinto ezichaphazelekayo kwi-membrane e-Ig E echanekileyo. Ukungena kwabo kwisithuba se-intercellular kukhokelela ekuphuculweni kwangoko kwendlela yokuphendula ngokukhawuleza. Ibonakala ngokwalo fomu:
- rhinitis;
- i-asthma;
- bronchitis;
- ukukhawuleza okukhulu.
Ingayenza kwakhona indlela yokuphendula inkqubo (ngokuqhelekileyo ngendlela yokutshatyalaliswa kwe-anaphylactic).
Kutheni kwaye njani ukuhlalutya i-immunoglobulin E?
Uhlalutyo lwe-immunoglobulin E jikelele lisetyenziselwa ukuxilongwa kwezifo ezahlukahlukeneyo zezifo kunye nokufumanisa izifo ezithintekayo. Ukuxilonga i-allergies, akwanele nje ukufumanisa ukuba i-Ig E iyonke iphakanyisiwe egazini. Kubalulekile ukuchonga i-allergen enomdla kunye ne-antibodies ethile. Kodwa izinga le-Ig E likuvumela ukuba ukhawuleze ukuhlula izifo ezivuthayo ezifayo ezivela kwizifo ezithathelwanayo ezinomfanekiso ofanayo wekliniki, kwaye ukuchonga izifo ezixhatshazwayo kunye nokukhetha unyango olwaneleyo.
Ngaphambi kokuthatha i-immunoglobulin E jikelele, akukho mfuneko efanelekileyo yokuqeqesha. Kufuneka kuphela ukuba ungadli phambi kohlalutyo. Uninzi lwamaxesha amaninzi, uvavanyo olunjalo lwebhubhoratri luyalelwe:
- i-scabi ;
- isikhumba;
- kubetha.
I-Angioedema kunye ne-urticaria engapheliyo ayikho imiqondiso eqingqiweyo yokuzimisela i-immunoglobulin ye-E, ekubeni ingabikho-mzimba.
Ukunyuswa kwe-intlanzi ye-IgE kubonisa ntoni?
Izinto ezisetyenziswayo ukuzimisela i-immunoglobulin epheleleyo i-serum yegazi. Amanqanaba aphezulu e-Ig E kuwo ayaqaphela xa:
- Pollinosis;
- ukutya kokutya;
- i-bronchitis ye-asthmatic;
- urticaria;
- Isifo seStevens-Johnson ;
- Edema ka Quincke;
- i-asthma ye-bronchial.
Ukwanda kwenani le-immunoglobulin E lihlala liphawulwa nge-atopic dermatitis, isifo se-serum, isifo sika-Lyell kunye nesisifo sokungabikho kwemithi. Ngamanye amaxesha izinga le-Ig E liphezulu kunelo liqhelekileyo, ukuba umntu unesifo se-helminthic, i-syndrome
Iimpawu zokuchazwa kweziphumo ze-Ig Ig ukuhlalutya?
I-immunoglobulin epheleleyo i-E ibonisa ukuba umntu une-ataxia-telangiectasia syndrome okanye i-immunodeficiency. Ngaba iziphumo zohlalutyo oluqhelekileyo? Oku akukubandakanyi ubukho bezinto ezibonakalayo. Ngokomzekelo, i-30% yezigulane ezinezifo ze-atopic zinamazinga ase-Ig E ngaphakathi kwesiqhelo. Ukongezelela, abanye abantu abane-asthma ye-bronchial banokuvakalelwa kwi-allergen eyodwa kuphela. Ngenxa yoko, banesigqeba esiqhelekileyo se-Ig E banokuhlala behlala kwinqanaba eliqhelekileyo.