Kwimichiza yanamhlanje kunye ne-pharmacology, ezinye iziphumo zifumaneka rhoqo. Yonke into eyenziwa ukwenza kube lula unyango lwezifo ezithile. Enye yezinto ezithembekileyo ezithembekileyo zi-antioclonal antibodies. Uninzi lweengqamzana eziveliswa ngumzimba zi-polyclonal. Ngokucacileyo, zenzelwe ukulwa nama-antigen ahlukeneyo, okunciphisa kakhulu ukuphumelela kwonyango. Amagciwane omzimba aseMonoclonal enza ngenjongo, avumela ukuba bafumane umphumo omkhulu kunokwenzeka.
Imigaqo yonyango kunye nama-antibodies
Okwangoku, iintsholongwane zamanye amazwe zisetyenziselwa ukujoliswa okanye ekuthiwa unyango olujoliswe kuyo. Njengoko iimvavanyo ziboniswa, le ndlela ibonisa iziphumo ezingcono zonyango.
Ama-antibodies e-Monoclonal ngamagciwane aphuma kwi-clone enye yamaseli. Okokuthi, bonke banomnye owodwa owandulela iseli. Ukusetyenziswa kwamachiza omzimba aseMonoclonal:
- i-colitis ;
- i-rheumatoid arthritis;
- psoriasis;
- multiple sclerosis .
Banceda ukulwa neendlela ezinzima kakhulu ze-oncology.
Umgaqo wesenzo se-antioclonal anti-monoclonal ilula kakhulu: bayazibona ii-antigens ezithile kwaye banamathele kubo. Ngombulelo, isistim somzimba sisiphawule ngokukhawuleza ingxaki kwaye siqala ukulwa nayo. Enyanisweni, iintsholongwane zomzimba zivumela umzimba ukuba ugxothe ama-antigen ngokuzimela. Enye inzuzo enkulu ye-MCA kukuba ithintela kuphela iiseli eziguqulwe ngokulandelanayo ngaphandle kokulimaza impilo.
Ama-antioclonal monoclonal kwi-oncology
Kwizigulane ezininzi ezine-oncology, iziyobisi ezibandakanya iintsholongwane ze-monoclonal ziye zithemba kuphela lokubuyela kwizinto eziqhelekileyo. Inxalenye enkulu yezigulane ezinezikhumba ezinzima kunye nezibikezelo ezidakisayo emva kokuba unyango lubonakale luncedo.
Izinzuzo ze-ICA zicacile:
- Ukudibanisa kumaseli omhlaza, izifo zamanqwelana ezizodwa zingabonakali ngakumbi, kodwa ziyancipha. Kwaye kunye neeseli ezithintekayo ezinokuguqulwa kwamathambo, umzimba ulula ukulwa.
- Ama-antibodies e-monoclonal afunyenwe nenjongo ekuthintela ukukhusela i-receptors yokukhula kwesisu. Ndiyabulela kule nyango ye-oncology ilula kakhulu.
- Ama-antibodies atholakala kwibhubhoratri, apho zidibaniswe ngokuthe ngqo kunye nenani elincinci lama-particle reactive. Ukugqithisa la maqhekeza emzimbeni, i-MCA ibanikela ngqo kwi-tumor, apho bayenza khona.
Ukunyangwa komhlaza kunye namayeza omzimba angafaniswa ne-radiotherapy. Kodwa ngokungafani neyokugqibela, i-ICA yenza izinto ezinzima. Injongo yabo yenza ukuba kusetshenziswe inani elincinci lee-particle reactive.
Iziyobisi ezinama-antibodies angama-monoclonal
Nangona i-ICA yaqulunqwa kungekudala, uluhlu lwamalungiselelo equle luvele lubonakala lukhangeleka kakhulu. Amayeza amasha avela rhoqo.
Izidalwa ezinqabileyo ezithandwayo zeso-monoglonal ezisetyenziswa namhlanje kwi-psoriasis, i-multiple sclerosis, umdlavuza, isifo se-rheumatoid, i-colitis ibonakala ngathi:
- Alemtuzumab;
- Alefacept;
- Daclusimab;
- Okrelizumab;
- Ustenkinumab;
- Basiliximab;
- Ofatumumab;
- Epratuzumab;
- Clenoliximab;
- Bevacizumab;
- Trastuzumab;
- Adalimumab;
- Enbrel;
- Infliximab nabanye.
Ngokuqinisekileyo, izilwanyana zamanqindi, njengezinye ezininzi iziyobisi, zinokuchaphazeleka. Ngokuqhelekileyo, izigulane emva kokusebenzisa i-ICA zikhalaza ngokubonakaliswa kweempendulo: ukubetha, ukukhawuleza. Kwiimeko ezinqabileyo, unyango luhambelana neengcamango, ukuhlanza okanye isifo sengqondo.