I-Angiotensin-ukuguqula i-enzyme iguqula i-angiotensin-ndiyi-angiotensin II. Kwaye okokugqibela, njengoko kuyaziwayo, kwandisa ngokunyanzeliswa kwegazi kubantu. Oku kwenziwa ngokunciphisa izitya, kunye nokuphonsa i-aldosterone. Ukuvimba i-angiotensin, i-ACE inhibitors ingasetyelwa.
Ngaloo ndlela, izidakamizwa ze-ACE inhibitor zingama-anti-anttentensive agents ezamkelwe ngempumelelo kwiminyaka engaphezu kwe-30 kwi-blood pressure. Ukuphucula umphumo we-inhibitor ucebise ukuba uthathe ngokubambisana ne-diuretic.
Uhlobo lwe-ACE inhibitors
Xa ukwahlula amayeza, ulwahlulo oluthile luyasetyenziswa. Ngaloo ndlela, ngokwexesha leempembelelo, loo maqela eziyobisi ahlukeneyo:
- Ukutshatyalaliswa kwexesha elifutshane. Ukusebenza kwezi mpahla kuqhubeka malunga neeyure ezingama-5-6. Ukuba awuyi kuthatha ipilisi elandelayo ngexesha, kunokungena ngokukhawuleza kwixinzelelo phezulu. Ziquka, umzekelo, iCaptopril , enokuthi ithatyathwe kumaxesha amathathu ngosuku.
- Ithetha ngempembelelo ephakathi. Ziyasebenza malunga neeyure eziyi-12. Misela ezi ziyeza kabini ngosuku - ngokuqhelekileyo kusasa nangokuhlwa. Ummeli oyintloko kweli qela lamathebulethi-inhibitors ze-ACE - Enalapril .
- Amachiza athatha ixesha elide. Le mali iyakwamkelwa ngokukhawuleza emva kwentsuku. Nangona kunjalo, kwiimeko ezibucayi, ukwamkelwa kwexesha ezimbini kunokwenzeka. Eli qela liquka uRamipril , uLisinopril nabanye. Kwilinye iqela lamayeza kukho ezo, umphumo walo ogcinwa kude kube ngu-48 iiyure emva kwepilisi yokugqibela.
Ukuqwalasela iimpawu ze-pharmokinetic, amaqela alandelayo ayahluka:
- amayeza apho isithako esisebenzayo sikhona;
- prodrugs.
Kwakhona, i-ACE inhibitors yesizukulwana esitsha ihlelwa ngokweendlela ezilandelayo zokuphelisa:
- ukupheliswa kweentso (zomyalelo we-70%);
- ukuphuma ngaphandle kwindlela yokucoca kunye ne-cholagogic;
- Ukugqitywa kunye ne-bile ngephepha lesisu.
Ukwahlula okunjalo kweziyobisi kulungelekile kuba ugqirha angakwazi ukuchaza ngokufanelekileyo oko okufanelekileyo kwesi sigulane esivela kuluhlu olubanzi lwezixhobo zonyango. Zonke iingenelo zokulungiselela nokuzikhethela kwefuthe layo kummandla ziqwalaselwe apha.
Imiphumo emibi ye-ACE Inhibitors
Ngona i-ACE inhibitor engcono kakhulu inika imiphumo emibi:
- ukukhwehlela okukhulu, echukunyiswa kukuqokelela kwe-bradykinin kwindlela yokuphefumula;
- hypotension ;
- buthathaka;
- intetho ethile emlonyeni;
- ukunyuka kwi-creinine;
- I-Hyperkalemia, izinga eliqhelekileyo ngokuthatha i-diuretics;
- ukungahambi;
- ukugqithisa kwezifo ezidibeneyo, njl
Ukubonakala ubuncinane kwoluhlu lwezityalo ezichaphazelekayo sizathu sokuthintela ngokukhawuleza ukuba ugqirha oza kuhamba kunye nezinye iziyobisi. Ukuba uyayigatya loo ma-alamu okanye uzama ukukhetha izidakamizwa ngokwakho, unokwandisa nje imeko.
Ukungqinelana kokungena kwi-ACE inhibitors
Kukho inani lemiqathango apho ukusetyenziswa kwee-ACE inhibitors imishanguzo ayinqatshelwe. Ezi ziquka:
- khulelwa;
- i ntliziyo;
- i-stenosis yomthambo oya kwiintso;
- hyperkalemia;
- arthritis;
- ixesha lokuhlamba;
- hypotension;
- ukunganyamezelani njalo njalo.
Kuzo zonke iimeko ezikhankanywe apha ngasentla, ukulawulwa kwezidakamizwa ze-ACE inhibitor kulungele kuphela ukuba omnye unyango alusebenzi. Kule meko, ugqirha emva kokuvavanya ngokugqithisileyo kwesigulane kufuneka ulinganiswe malunga neengozi ezinokubakho kunye neenzuzo zangempela.