Iprokinetics ngamachiza asemagqabini esondlo somzimba. Inyaniso enomdla idibene nabo. Uluhlu lwezilwanyana zonyango, oluya kuqatshelwa yizo zonke i-gastroenterologists, azikho. Iingcali ezahlukeneyo zichaza ngokucacileyo uluhlu olunjalo. Ziziphi i prokinetics?
Abaphikisi beprokinetic of receptors
Impembelelo yabachasene neprokine i sekelwe kwinto yokuba ibophe ngokukhawuleza kwi-D2-dopamine receptors kwaye iyanciphisa kakhulu impendulo yabo kwimpawu zomzimba zomzimba. Ngombulelo banceda ekusebenzeni umsebenzi wemoto yesisu, kunye nokukhuthaza isenzo se-antiemetic. Uludwe lwezilwanyana ezifana neprokine lubandakanya:
- Bromopride;
- Domperidone;
- Metoclopramide;
- Dimetramipid.
Ngokuqhelekileyo, zonke zizisetyenziselwa unyango lwe-stermidalinal tract Domperidone, nangona iprokinetic yesizukulwana sesibini. Oku kubangelwa kukuba akukho miphumo ebalulekileyo yecala.
Ezinye iingcali zibhekisela kweli qela labachasi kunye ne-Itopride. Kodwa ngokusemthethweni le nto ayibonakaliyo, kuba inemiphumo yokuvimbela i-acetylcholine. Kwakhona kweli qela leprokinetics zilungiselelwe isizukulwana sokuqala sikaReglan noCerukal. Yaye yonke into ngenxa yesithako sayo esisebenzayo yi-metoclopramide. Ngaphantsi kweemeko ezithile, kunokudala i-tachycardia, i-tinnitus, ukulala nokusila.
Abachasayo beprokine basetyenziswa xa:
- i-achalasia ye-esophagus ;
- isilonda sesisu okanye i-duodenum;
- ukutywa kwamathumbu, okwenzeka emva kwemisebenzi;
- ukuguquka;
- unyango lwe-reflux ye-gastroesophageal disease;
- esebenzayo dyspepsia;
- ukuphazamiseka okukhulu kweengxube ze-bile.
Kwiimeko ezinqabileyo, iziyobisi eziyinxalenye yeli qela zinokumiselwa izifo zesibindi kunye nesibindi, ukuhlanza nokufudumala okubangelwa zizifo ezithathelwanayo, okanye kunye neyeza zonyango. Zihlala zisetyenziselwa ukukhusela ukuhlanza ngaphambi kokugcina i-endoscopy okanye izifundo ezahlukeneyo ze-radiopaque.
Iprokinetics-ivuselela ama-intestinal peristalsis
Iprokinetics eyaziwa kakhulu kweli qela yilungiselelo eliphethe amagama kaCordax noMozapride. Ziyafana kakhulu ngendlela yokusebenza. Ziyahluka kuphela kuloo Mozapride ayinasiphumo kwisenzo somzila we potassium, kwaye oku kunciphisa kakhulu umngcipheko wokuphazamiseka kwengqondo yomzimba.
Eli qela libandakanya ezo zonyango njenge:
- Aceclidine;
- Isiqinisekiso;
- Physiostigmine;
- Pyridostigmine bromide;
- Galantamine;
- Neostigmine monosulfate.
Iprokinetics-agonists ye-receptors ye-motilin
Iziyobisi zeprokine zibandakanya iziyobisi ezibophelela kwi-moptin receptors (i-hormone eyanceda ukwandisa uxinzelelo kwi-sphincter engaphantsi, eyinceda ukukhupha). Ezi ziquka:
- Azithromycin;
- Clarithromycin;
- Atilmotine;
- Erythromycin.
Ezi zi yobisi zikhokelela ekuqheqweni kwamandla omzimba. Ngenxa yoko, isisu sisuka kwindawo yokutya okanye isondlo. Kwakhona, ixesha lokuhamba kwimixholo emathunjini amakhulu liyancipha kakhulu, nakwiimeko ezithile zentsholongwane, umzekelo, kunye nesifo sikashukela segastroparesis okanye i-systemic scleroderma.
Ukuba unikwe i-prokinetic agonists ye-receptor ye-motilin, qaphela ukuba unemiphumo emibi. Ngokomzekelo, i-Erythromycin, ithathwa ngaphezu kweenyanga, inokunyusa umngcipheko wokufa ngenxa yokuziphatha okungaqhelekanga kwimizimba.